Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (9): 3312-3318.DOI: 10.6023/cjoc202301024 Previous Articles     Next Articles

腐殖酸作用下Strecker反应快速高效合成α-氨基腈

席敏, 段超, 迟捷, 付甜, 苏小龙, 王宏社*()   

  1. 宝鸡文理学院化学化工学院 陕西省植物化学重点实验室 陕西宝鸡 721013
  • 收稿日期:2023-01-29 修回日期:2023-03-26 发布日期:2023-05-11
  • 基金资助:
    国家自然科学基金(51902004); 陕西省自然科学基金(2020KW-041)

An Efficient and Rapid Synthesis of α-Aminonitriles via Strecker Reaction Catalyzed by Humic Acid

Min Xi, Chao Duan, Jie Chi, Tian Fu, Xiaolong Su, Hongshe Wang()   

  1. Shaanxi Key Laboratory for Phytochemistry, Department of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, Shaanxi 721013
  • Received:2023-01-29 Revised:2023-03-26 Published:2023-05-11
  • Contact: E-mail: hongshewang@126.com
  • Supported by:
    National Natural Science Foundation of China(51902004); Natural Science Foundation of Shaanxi Province(2020KW-041)

An efficient one pot three-component Strecker reaction for the green synthesis of α-aminonitriles from carbonyl compounds, amines and trimethylsilyl cyanide (TMSCN) in the presence of a catalytic amount of humic acid catalyst under solvent-free conditions at room temperature has been developed. This methodology has advantages of high yield, no need for metal catalysts, short reaction time, mild reaction conditions, simple operation, green and reusable catalyst.

Key words: Strecker reaction, humic acid, carbonyl compound, amine, α-aminonitrile