Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (1): 1-17.DOI: 10.6023/cjoc202307028 Previous Articles     Next Articles

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烷氧自由基引发1,5-氢原子转移实现C(sp3)—H键官能团化的研究进展

朱彦硕a, 王红言c, 舒朋华a, 张克娜a, 王琪琳b,*()   

  1. a 许昌学院食品与药学院 河南许昌 461000
    b 河南大学化学与分子科学学院 河南开封 475004
    c 许昌学院继续教育学院 河南许昌 461000
  • 收稿日期:2023-07-31 修回日期:2023-09-26 发布日期:2023-10-30
  • 基金资助:
    国家自然科学基金(22101073); 中国博士后科学基金(2020M672200); 及河南省高等学校重点科研(24A350016)

Recent Advances on Alkoxy Radicals-Mediated C(sp3)—H Bond Functionalization via 1,5-Hydrogen Atom Transfer

Yanshuo Zhua, Hongyan Wangc, Penghua Shua, Ke'na Zhanga, Qilin Wangb()   

  1. a Food and Pharmacy College, Xuchang University, Xuchang, Henan 461000
    b College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004
    c School of Continuing Education, Xuchang University, Xuchang, Henan 461000
  • Received:2023-07-31 Revised:2023-09-26 Published:2023-10-30
  • Contact: *E-mail: wangqilin@henu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(22101073); China Postdoctoral Science Foundation(2020M672200); Foundation of He'nan Educational Committee(24A350016)

Intramolecular hydrogen atom transfer (HAT) has proved to be an effective method to achieve the selective functionalization of remote C—H bonds. In this fascinating research area, alkoxy radicals have emerged as an important intermediate to participate in intramolecular hydrogen atom transfer reactions. In particular, the burgeoning visible-light photoredox catalysis has provided a new platform for O-radical directed remote functionalization of C(sp3)—H bonds. The progress on the different mechanisms of alkoxy radical generation and their applications in the intramolecular 1,5-HAT reactions for remote C(sp3)—H bond functionalization in the past five years are comprehensively summarized.

Key words: visible light photocatalysis, alkoxy radical, remote functionalization, 1,5-hydrogen atom transfer (1,5-HAT)