Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (1): 224-231.DOI: 10.6023/cjoc202309003 Previous Articles     Next Articles



孟宪强a,b, 杨艺a, 梁万洁b, 王靖涛c, 张荣葵d,*(), 刘会a,c,d,*()   

  1. a 山东理工大学化学化工学院 山东淄博 255049
    b 山东安得医疗用品股份有限公司 山东淄博 255086
    c 天津大学化工学院 天津 300072
    d 淄博市中心医院无菌供应中心 山东淄博 255020
  • 收稿日期:2023-09-04 修回日期:2023-09-12 发布日期:2024-01-31
  • 基金资助:

Palladium-Catalyzed Regioselective Aryl Phenoxylation of Allenamide

Xianqiang Menga,b, Yi Yanga, Wanjie Liangb, Jingtao Wangc, Rongkui Zhangd(), Hui Liua,c,d()   

  1. a School of Chemistry & Chemical Engineering, Shandong University of Technology, Zibo, Shandong 255049
    b Shandong Ande Healthcare Apparatus Co., Ltd., Zibo, Shandong 255086
    c School of Chemical Engineering, Tianjin University, Tianjin 300072
    d Central Sterile Supply Department, Zibo Central Hospital, Zibo, Shandong 255020
  • Received:2023-09-04 Revised:2023-09-12 Published:2024-01-31
  • Contact: *E-mail:; E-mail:
  • Supported by:
    National Natural Science Foundation of China(22078178)

A palladium-catalyzed regioselective aryl phenoxylation of allenamide with phenol derivatives has been developed, providing valuable branched allyl ether products in moderate to excellent yields under mild reaction conditions. Importantly, only the proximal addition products of allenamide were observed in the reaction process, and no distal addition products were observed. A coordinated palladium complex was proposed to be responsible for the excellent proximal addition in the insertion step. The final nucleophilic attack at α-position was induced by the steric effect of palladium complex.

Key words: palladium-catalysis, proximal addition, aryl phenoxylation