Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (5): 1667-1674.DOI: 10.6023/cjoc202311026 Previous Articles     Next Articles

ARTICLES

Na2S2O8介导的咪唑并[1,2-α]吡啶与杂芳胺在无金属条件下的C—H胺化反应

孙一平a, 陈德茂b, 何玲c,*(), 王祖利b,*()   

  1. a 中国科学院兰州化学物理研究所 固体润滑国家重点实验室 兰州 730000
    b 青岛农业大学化学与药学院 青岛 266109
    c 重庆大学药学院创新药物研究中心 天然产物合成与药物研究重庆重点实验室 重庆 401331
  • 收稿日期:2023-11-24 修回日期:2024-01-02 发布日期:2024-01-11
  • 基金资助:
    国家自然科学基金(21772107); 山东省高等学校青创人才引育计划(2021)

Na2S2O8 Mediated C—H Amination of Imidazo[1,2-α]pyridines with Heteroaromatic Amines under Metal-Free Conditions

Yiping Suna, Demao Chenb, Ling Hec(), Zuli Wangb()   

  1. a State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000
    b College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109
    c Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331
  • Received:2023-11-24 Revised:2024-01-02 Published:2024-01-11
  • Contact: *E-mail: wangzulichem@163.com, heling2015@cqu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(21772107); Youth Innovation Team Project for Talent Introduction and Cultivation in Universities of Shandong Province(2021)

A highly efficient and practical amination protocol for imidazo[1,2-α]pyridines using heteroaromatic amines was developed. Notably, the transformation proceeds without the need for any metal catalyst. Isolation of products bearing diverse substituents was achieved in moderate to high yields.

Key words: imidazo[1,2-α]pyridines, persulfates, heteroaromatic amines, green organic synthesis