Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities

doi:10.6023/cjoc202404024

Chinese Journal of Organic Chemistry

NOTE

红树植物海漆中二萜类化合物及其抗神经炎症活性

李俊义^a,†, 杨璐^b,†, 陈明宾^a, 饶勇^a, 江仲平^*,a, 黄玲^*,a

^a海南大学热带生物资源教育部重点实验室,海南大学药学院海口 570228;
^b海南大学食品科学与工程学院海口 570228

收稿日期:2024-04-17 修回日期:2024-05-27
基金资助:
国家自然科学基金(No. 82204275和82160653 )、海南省自然科学基金(323MS014)资助项目.

Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities

Li, Junyi^a,†, Yang, Lu^b,†, Chen, Mingbin^a, Rao, Yong^a, Jiang, Zhongping^*,a, Huang, Ling^*,a

^aKey Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228;
^bSchool of Food Science and Engineering, Hainan University, Haikou, 570228

Received:2024-04-17 Revised:2024-05-27
Contact: *E-mail: zpjiang@hainanu.edu.cn; Linghuang@hainanu.edu.cn
About author:† These authors contributed equally to this work.
Supported by:
National Natural Science Foundation of China (No. 82204275 and 82160653), the Hainan Provincial Natural Science Foundation of China (323MS014)

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Abstract

In this paper, normal-phase and reversed-phase silica gel column chromatography and semi-preparative high performance liquid chromatography were applied to study the chemcal constituents of the stems and twigs of the Hainan mangrove plant, Excoecaria agallocha L.. A new 3,4-seco-ent-kaurane diterpenoid, named agallochanin acid A (1), and a rare ent-tetranorlabdane diterpenoid, named agallochanin acid B (2), along with four known diterpenoids (3-6) were isolated. Their structures including absolute configurations were characterized via HR-ESIMS, extensive 1D and 2D NMR investigations and calculated and experimental electronic circular dichroism (ECD) data. All isolates were tested for their inhibitory effects on NO production in LPS-activated BV-2 cells. Compounds 3 and 5 exhibited considerable anti-neuroinflammatory activities, with IC₅₀ values of 14.32 ± 1.99 and 4.24 ± 0.37 μM.

Key words: Excoecaria agallocha L., mangrove plant, kaurane diterpenoid, labdane diterpenoid, anti-neuroimflamation

Cite this article

Li, Junyi, Yang, Lu, Chen, Mingbin, Rao, Yong, Jiang, Zhongping, Huang, Ling. Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202404024.

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红树植物海漆中二萜类化合物及其抗神经炎症活性

Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities

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