Indium-Promoted Efficient Synthesis of Se-Aryl- 2,2-Dimethylbutaneselenoates

doi:10.6023/cjoc202507026

Chinese Journal of Organic Chemistry Next Articles

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铟促进的硒代芳基-2,2-二甲基丁硒酸酯的高效合成

杨凯^†a, 单申^†a, 陈伟铭^a, 黄九忠^a, 张毅^a, 吴庆荣^*,b, 吴高荣^*,a

^a赣南医科大学药学院, 江西省中药药理重点实验室赣州 341000
^b赣州市第五人民医院药剂科,赣州肝病研究所赣州 341000

收稿日期:2025-07-19 修回日期:2025-09-23
作者简介:^†共同第一作者
基金资助:
江西省职业早期青年科技人才培养专项项目(No. 20244BCE52224),江西省自然科学基金(No. 20252BAC200240)资助项目.

Indium-Promoted Efficient Synthesis of Se-Aryl- 2,2-Dimethylbutaneselenoates

Yang, Kai^†a, Shan, Shen^†a, Chen, Weiming, Huang, Jiuzhong, Zhang, Yi, Wu, Qingrong^*,b, Wu, Gaorong^*,a

^aJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou, 341000
^bDepartment of Pharmacy, Ganzhou Liver Institute, Ganzhou Fifth People's Hospital, Ganzhou 341000

Received:2025-07-19 Revised:2025-09-23
Contact: ^*E-mail: gzwywqr@126.com; gaorongwu09@163.com
Supported by:
Early-Career Young Scientists and Technologists Project of Jiangxi Province (No. 20244BCE52224), Jiangxi Provincial Natural Science Foundation (No. 20252BAC200240).

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Abstract

Selenoester compounds exhibit significant biological activity and are widely used in the synthesis of natural products, protein intermediates, and superconducting materials. However, current methods for constructing selenoesters suffer from drawbacks such as expensive catalysts, multiple reaction steps, low yields, and poor efficiency to sterically hindered acyl chlorides. Here, an efficient indium-promoted method for the synthesis of Se-aryl-2,2-dimethylbutaneselenoates is developed. The strategy features broad substrate scope, mild reaction conditions and simple operation, offering the desired products in moderate to excellent yields. Furthermore, the gram-scale reaction can be conducted smoothly, laying the foundation for subsequent derivatization of such structures.

Key words: organoselenium compounds, indium-promoted, Se-aryl-2,2-dimethylbutaneselenoates

Cite this article

Yang, Kai, Shan, Shen, Chen, Weiming, Huang, Jiuzhong, Zhang, Yi, Wu, Qingrong, Wu, Gaorong. Indium-Promoted Efficient Synthesis of Se-Aryl- 2,2-Dimethylbutaneselenoates[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202507026.

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铟促进的硒代芳基-2,2-二甲基丁硒酸酯的高效合成

Indium-Promoted Efficient Synthesis of Se-Aryl- 2,2-Dimethylbutaneselenoates

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