Direct synthesis of β-hydroxyesters via cobalt-catalyzed carbonylation of epoxides

doi:10.6023/cjoc202602005

Chinese Journal of Organic Chemistry

ARTICLE

钴催化环氧化物羰基化反应合成β-羟基酯

刘德洋, 周涛^*, 史炳锋^*

浙江大学化学系土壤污染防治与安全全国重点实验室杭州 310027

收稿日期:2026-02-03 修回日期:2026-03-23

Direct synthesis of β-hydroxyesters via cobalt-catalyzed carbonylation of epoxides

De-Yang Liu, Tao Zhou^*, Bing-Feng Shi^*

State Key Laboratory of Soil Pollution Control and Safety, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.

Received:2026-02-03 Revised:2026-03-23
Contact: * E-mail: taozhou@zju.edu.cn, bfshi@zju.edu.cn
Supported by:
National Natural Science Foundation of China (22525011, U25A20547, U22A20388, 92256302 for Bing-Feng Shi, 22271250 for Tao Zhou), and Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM407).

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Abstract

β-Hydroxyesters are important skeletons in numerous bioactive compounds, pharmaceuticals, and natural products. We report here a highly efficient and straightforward method for synthesizing β-hydroxy esters via cobalt-catalyzed carbonylation of epoxides with carbon monoxide using tri(pyridin-2-yl)phosphane as the ligand. Both monosubstituted and disubstituted epoxides are well tolerated in the reaction.

Key words: cobalt-catalyzed, epoxides, carbonylation, β-hydroxyesters

Cite this article

De-Yang Liu, Tao Zhou, Bing-Feng Shi. Direct synthesis of β-hydroxyesters via cobalt-catalyzed carbonylation of epoxides[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202602005.

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钴催化环氧化物羰基化反应合成β-羟基酯

Direct synthesis of β-hydroxyesters via cobalt-catalyzed carbonylation of epoxides

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