Progress in the Synthesis of 1,3-Disubstituted Ferrocene

doi:10.6023/cjoc202607018

Chinese Journal of Organic Chemistry

REVIEW

1,3-二取代二茂铁的合成进展

胡瑞昕^#, 黄啸^#, 矫诚康^*, 周强辉, 程鸿刚^*

武汉大学化学与分子科学学院武汉 430072

收稿日期:2026-07-16 修回日期:2026-08-02
作者简介:^#共同第一作者
基金资助:
国家自然科学基金（Nos. 22325106, 22471204）及江苏省自然科学基金（No. BK20210119）资助项目;

Progress in the Synthesis of 1,3-Disubstituted Ferrocene

Hu Ruixin^#, Huang Xiao^#, Jiao Chengkang^*, Zhou Qianghui, Cheng Hong-Gang^*

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072

Received:2026-07-16 Revised:2026-08-02
Contact: *E-mail: 2021202030059@whu.edu.cn; hgcheng@whu.edu.cn
About author:^#These authors contributed equally to this work.
Supported by:
National Natural Science Foundation of China (Nos. 22325106 and 22471204) and Natural Science Foundation of Jiangsu Province (no. BK20210119).

Ferrocene is a kind of functional molecule which is widely used in catalysis, medicine, materials and other fields. Compared with the extensive synthesis of 1,2-disubstituted ferrocenes, the synthesis of 1,3-disubstituted ferrocenes, especially the planar-chiral 1,3-disubstituted ferrocenes, is relatively limited. This review summarizes recent progress on the development of novel methods to synthesize 1,3-disubstituted ferrocenes and their planar-chiral derivatives. In addition, the application of these synthetic methods in the preparation of planar-chiral functional materials, 1,3-disubstituted planar-chiral ferrocene ligands as well as their utilization in catalytic asymmetric reactions are also described.

Key words: 1,3-disubstituted ferrocene, planar chirality, synthesis

Cite this article

Hu Ruixin, Huang Xiao, Jiao Chengkang, Zhou Qianghui, Cheng Hong-Gang. Progress in the Synthesis of 1,3-Disubstituted Ferrocene[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202607018.

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1,3-二取代二茂铁的合成进展

Progress in the Synthesis of 1,3-Disubstituted Ferrocene

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