Asymmetric reduction of ketones using optically active N,N-dialkyl-β-aminoalcohol-borane complexes

Chin. J. Org. Chem. ›› 1995, Vol. 15 ›› Issue (1): 39-46. Previous Articles Next Articles

Original Articles

光学活性N,N-二烷基-β-氨基醇硼烷配合物对酮的不对称还原反应

赵军;周望岳;杨世琰;金道森

浙江工业大学化学工程系;中国科学院兰州化学物理研究所

发布日期:1995-02-25

Asymmetric reduction of ketones using optically active N,N-dialkyl-β-aminoalcohol-borane complexes

ZHAO JUN;ZHOU WANGYUE;YANG SHIYAN;JIN DAOSEN

Published:1995-02-25

Abstract

Nine new optically active N,N-dialkyl-β-aminoalcohlos synthesized from natural amino acids reacted with borane in THF to give chiral oxazoborolidines. The borane modified by chiral oxazoborolidines enantioselectively reduced aliphatic and aromatic ketones to yield sec-alcohlos with 100% yield and medium to high optical yields. Some influences of steric effect, reaction temperature and solvent effects were discussed.

Key words: REDUCTION REACTION, BORANE, BORANES, ASYMMETRY, AMINO ALCOHOL

CLC Number:

O621

Cite this article

ZHAO JUN;ZHOU WANGYUE;YANG SHIYAN;JIN DAOSEN. Asymmetric reduction of ketones using optically active N,N-dialkyl-β-aminoalcohol-borane complexes[J]. Chin. J. Org. Chem., 1995, 15(1): 39-46.

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光学活性N,N-二烷基-β-氨基醇硼烷配合物对酮的不对称还原反应

Asymmetric reduction of ketones using optically active N,N-dialkyl-β-aminoalcohol-borane complexes

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