Synthesis and crystal structures of 3-acetyl-substituted pyrroles

Abstract

Four new 3-acetyl substituted pyrrole derivatives were prepared by Knorr-pyrrole synthetic method: 5a, 1, 2-dimethyl-4-isopropyl-5-phenyl -3-acetyl pyrrole; 5b, 1, 2, 4-trimethyl-5-p-methoxyphenyl-3-acetyl pyrrole; 5c, 1, 2, 5-trimethyl-4-phenyl-3-acetyl pyrrole; 5d, 1, 2, 5- trimethyl-4-p-methoxyphenyl-3-acetyl pyrrole. Their structures were identified by IR, ^1H NMR and MS Spectroscopy. Crystal structures of compound 5a, 5b and 5c were obtained by X-ray analysis. The structure characters of this kind of molecules were discussed. The results show that the phenyl group located in the 4- or 5- position of pyrryl ring are not coplanar with the pyrryl ring.

Key words: INFRARED SPECTROPHOTOMETRY, CRYSTAL STRUCTURE, ACETYL GROUP, MASS SPECTROGRAPHY, PYRROLE P, NMR SPECTROMETRY

CLC Number:

O621

Cite this article

YU LIANHE;MING YANGFU;FAN MEIGONG;ZHU YING. Synthesis and crystal structures of 3-acetyl-substituted pyrroles[J]. Chin. J. Org. Chem., 1996, 16(1): 53-63.

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