Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (6): 1565-1570.DOI: 10.6023/cjoc201608020 Previous Articles     Next Articles



张梅梅a, 王洁b, 刘建全a, 王香善a   

  1. a. 江苏师范大学化学化工学院 徐州 221116;
    b. 江苏师范大学科文学院 徐州 221116
  • 收稿日期:2016-08-24 修回日期:2016-12-24 发布日期:2017-02-08
  • 通讯作者: 王香善
  • 基金资助:


One-Pot and Three-Component Synthesis of Furopyridoquinoxaline Derivatives under Catalyst-Free Conditions

Zhang Meimeia, Wang Jieb, Liu Jianquana, Wang Xiangshana   

  1. a. School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116;
    b. Kewen College, Jiangsu Normal University, Xuzhou 221116
  • Received:2016-08-24 Revised:2016-12-24 Published:2017-02-08
  • Contact: 10.6023/cjoc201608020
  • Supported by:

    Project supported by the Major Basic Natural Science Foundation of University in Jiangsu Province (No. 14KJA150004) and the Natural Science Foundation of Jiangsu Normal University (No. 15XLA05).

A series of 11-aryl-8,11-dihydrofuro[3',4':5,6]pyrido[3,2-f]quinoxalin-10(7H)-one derivatives were obtained via a one-pot and three-component reaction of aromatic aldehydes, 6-aminoquinoxaline and tetronic acid in EtOH. The structure of 11-(4-nitrophenyl)-8,11-dihydrofuro[3',4':5,6]pyrido[3,2-f]quinoxalin-10(7H)-one (4g) was confirmed by X-ray diffraction analysis. This procedure had the advantages of operation simplicity, catalyst-free and without isolating intermediates, and provided a good method for the synthesis of fused tetracyclic heterocycles containing furan, pyridine and quinoxaline moieties at the same time.

Key words: furopyridoquinoxaline, 6-aminoquinoxaline, three-component reaction, crystal structure, synthesis