Chin. J. Org. Chem. ›› 2000, Vol. 20 ›› Issue (4): 510-513. Previous Articles     Next Articles

新法合成6-烷氧基和6-氨基鸟嘌呤核苷衍生物

林紫云;朱莉亚;梁晓天   

  1. 中国医学科学院中国协和医科大学药物研究所
  • 发布日期:2000-08-25

A novel method for synthesizing 6-alkoxy and 6-amino guanosine

Lin Ziyun;Zhu Liya;Liang Xiaotian   

  • Published:2000-08-25

A new method for preparing 6-alkoxy and 6-amino guanosine derivatives by reaction of N-acetyl-2',3',5'-tri-0-acetyl-guanosine, 4-ClPhOPOCl~2 and 1,2,4-Triazole in dry pyridine at room temperature via N-6-pyridinium intermediate(2) is presented. The chemistry and characterization of these compounds are also reported.

Key words: GUANOSINE, ALKOXYL GROUP, PYRIDINE, FURAN P, GUANINE

CLC Number: