Separation of racemic mixtures of thirty-eight secondary aromatic alcohols and arylethanediols with different substituting group was achieved with HPLC by using Chiralcel OD and Chiralcel LJ as chiral stationary phase and hexane/2-propanol mixtures of different ratios as eluents. The chromatographic parameters of these racemates on OD and OJ columns were examined. The results showed enantiomeric resolution ability of the racemic mixtures on these columns was strongly dependent on the site and the property of substituents. The hydrogen bonding and π-π interactions between the chiral stationary phase and the polar group o secondary aromatic alcohols and arylethanediols may be responsible for the chiral resolution. This method had been applied to determination of the optical purity of the asymmetric reduction products of prochiral ketones.

Key words: HIGH SPEED LIQUID CHROMATOGRAPHY, CHIRAL REAGENT, MESOTOMY, STATIONARY PHASE, AROMATIC ALCOHOL, ETHANEDIOL P