Asymmetric reduction of chiral titanium complexes of  α-keto aromatic acids with lithium dialkyl amides

Chin. J. Org. Chem. ›› 2002, Vol. 22 ›› Issue (1): 64-66. Previous Articles Next Articles

二烷基胺基锂对α-芳族酮酸手性钛盐的不对称还原反应

段新方;尹承烈

北京师范大学化学系.北京(100875)

发布日期:2002-01-25

Asymmetric reduction of chiral titanium complexes of α-keto aromatic acids with lithium dialkyl amides

Duan Xinfang;Yin Chenglie

Beijing Normal Univ., Dept of Chem..Beijing(100875)

Published:2002-01-25

Abstract

Chiral titanium complexes of α-keto aromatic acids(2), obtained by introducing chiral alkoxyligands into titanium complexes of the keto acids, were reduced by lithium dialkyl amides(3) yielding the corresponding mandelic acids in 8.3 to 24.9% ee.

Key words: HYDROXYCARBOXYLIC ACIDS P, ORGANO LITHIUM COMPOUNDS, LITHIUM REAGENT, ORGANOTITANIUM COMPOUNDS, AROMATIC COMPOUNDS, KETONE ACID, REDUCTION REACTION

CLC Number:

O627

Cite this article

Duan Xinfang;Yin Chenglie. Asymmetric reduction of chiral titanium complexes of α-keto aromatic acids with lithium dialkyl amides[J]. Chin. J. Org. Chem., 2002, 22(1): 64-66.

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二烷基胺基锂对α-芳族酮酸手性钛盐的不对称还原反应

Asymmetric reduction of chiral titanium complexes of α-keto aromatic acids with lithium dialkyl amides

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