Synthesis and Biological Activity of Novel Bis-heterocyclic Compounds Containing 1H-Pyrazole and Thiazole

Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (10): 1131-1134. Previous Articles Next Articles

含1H-吡啶和噻（二）唑的新型双杂环化合物的合成及其生物活性

胡利明;李学恕;陈致远;刘钊杰

华中师范大学有机合成研究所

发布日期:2003-10-25

Synthesis and Biological Activity of Novel Bis-heterocyclic Compounds Containing 1H-Pyrazole and Thiazole

Hu Liming;Li Xueshu;Chen Zhiyuan;Liu Zhaojie

Institute of Organic Synthesis, Central China Normal University

Published:2003-10-25

Abstract

In order to search for novel fungicides with high activity and low toxicity, a series of bis-heterocyclic compounds containing 1H- pyrazole and thiazole were designed and synthesized from phenyl hydrazine, ethyl acetoacetate and aromatic aminoheterolcycles. The structures of all new compounds were confirmed by elemental analysis, ~1H NMR, IR and MS spectra. Preliminary bioaasays indicated that some compounds showed fungicidal activity against Pellicularia sasakii, Gibberella zeave and Physalospora piricola.

Key words: PYRAZOLE P;AMIDES P;BENZOTHIAZOLE;THIADIAZOLE;BACTERICIDAL AGENTS, PHENYLHYDRAZINE;ACETOACETIC ACID P

CLC Number:

O621

Cite this article

Hu Liming;Li Xueshu;Chen Zhiyuan;Liu Zhaojie. Synthesis and Biological Activity of Novel Bis-heterocyclic Compounds Containing 1H-Pyrazole and Thiazole[J]. Chin. J. Org. Chem., 2003, 23(10): 1131-1134.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	MA Cha, LI Long, SUN Jin-Sheng, ZHAO Feng, LI Yi-Long. Recent Progress in Dansyl-Based Dendrimers [J]. Chin. J. Org. Chem., 2011, 31(12): 1977-1988.
[2]	LIU Bin, XIE Long-Guan, XU Xiao-Hua, LI Yong-Hong. Synthesis, Crystal Structure and Herbicidal Activity of 3-Benzoyl-4-hydroxycoumarin Derivatives [J]. Chin. J. Org. Chem., 2011, 31(12): 2067-2073.
[3]	WANG Gang-Qiang, CHEN Yu-Ling, HAN Ming-Song, SUN Liang, WANG Qiu-An. Synthesis and Biological Activity of Pterostilbene and 3-Methoxy Pterostilbene and Their Glucosides Derivatives [J]. Chin. J. Org. Chem., 2011, 31(12): 2114-2120.
[4]	ZHANG Hua-Cheng, LIU Zhao-Na, XIN Fei-Fei, LI Yue-Ming, KONG Li, HAO Ai-You. Atom Transfer Radical Polymerization Based on Cyclodextrin [J]. Chin. J. Org. Chem., 2011, 31(11): 1761-1772.
[5]	ZHANG Huan, LI Hai-Gang, WU Hai-Hong. Synthesis of Chiral Imidazolinone-Based Ionic Liquids [J]. Chin. J. Org. Chem., 2011, 31(9): 1433-1439.
[6]	. Synthesis and Antitumor Activity of 5,6-2H-[1,2,4]- triazolo [3,4-b][1,3,4]thiadiazine derivatives [J]. Chin. J. Org. Chem., 2011, 31(06): 912-920.
[7]	YI Bing, ZHANG Yang, SHU Xiao-Ma, YANG Yan, DU Wen-Le, LIU Zhan-Peng. Study on Henry Reaction Catalyzed by Dendritic Amines [J]. Chin. J. Org. Chem., 2011, 31(06): 874-877.
[8]	WEI Ben-Mei, ZHANG Zhi-Yong, DAI Zhi-Qun, ZHANG Kai-Cheng. Friedel-Crafts Benzylation of Aromatic Compounds Catalyzed by Chloroapatite Supported Metal Halides [J]. Chin. J. Org. Chem., 2011, 31(03): 392-396.
[9]	LIU Zhi-Chang, LIU Xiao-Xia, WANG Ying-Hong, YANG Lu. Synthesis and Biological Activities of N-Coumarin-3-formacyl-N - substitute Thioreas De-rivatives [J]. Chin. J. Org. Chem., 2011, 31(01): 136-140.
[10]	FAN Wen-Ming, GAO Jian-Rong, JIA Jian-Hong, HAN Liang, SHENG Wei-Jian, LI Yu-Jin. Solvent-Free Synthesis of β-Enamino Ketones (Esters) under High-Speed Vibration Miling (HSVM) Condition [J]. Chin. J. Org. Chem., 2010, 30(11): 1732-1736.
[11]	WANG Chao, ZHENG Xue-Fang, ZHANG Qian, LIU Qun. Progress in the Study of Different Position Substituted Thia-zolidine-4-carboxylic Acid and Its Derivatives [J]. Chin. J. Org. Chem., 2010, 30(10): 1441-1454.
[12]	XIONG Wen-Shuo, WANG Hong, YI Yu, MEI Jian-Feng, YING Guo-Qing. Progress of Crystallization-Induced Asymmetric Transformation in Resolution of Chiral Compounds [J]. Chin. J. Org. Chem., 2010, 30(07): 951-957.
[13]	YANG Xu-Hong, WU Ming-Hu, DING Ming-Wu. Synthesis of 2,2 -Disubstituted Bis(3-arylquinazolin-4(3H)-one)s [J]. Chin. J. Org. Chem., 2010, 30(07): 1032-1038.
[14]	LIU Chang-Chun, LU Wei-Ping, YAN Yan-Ning. Synthesis of Carbamates by Carbonylation of Floronitrobenzenes over TiO₂ Supported Pd-Fe Catalyst [J]. Chin. J. Org. Chem., 2010, 30(06): 843-848.
[15]	CAO Chen-Zhong, LIU Li-Qiu, CHEN Guan-Fan, ZHOU Zai-Chun, JIANG Rong-Qing, LEI Bing-Chao. Effect of Substituents on the Configuration of Stilbene Derivatives in Wittig Reaction of Substituted Benzaldehyde with Nitro-benzyltriphenylphosphonium Salt [J]. Chin. J. Org. Chem., 2010, 30(03): 395-400.

含1H-吡啶和噻（二）唑的新型双杂环化合物的合成及其生物活性

Synthesis and Biological Activity of Novel Bis-heterocyclic Compounds Containing 1H-Pyrazole and Thiazole

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments