Molecular parameters of alkanes (N, N', P, q and n ) can be used to characterize the size, the substitute parameters and the effect of neighboring substituent. According to N, N', P, q and n using as separate parameter, some physico-chemical properties for alkanes were predicted by regression method. Predicting values of atomization enthalpies, formation enthalpies, aporization enthalpies, molar volume and molar refrangibility are excellently consistent with the literature ones for alkanes that have 1～9 carbon atoms. The results showed that the model had the advantage of principle simple, method practicality and results credibility, and confidence degree high to 99. 5%.

Key words: ALKANE, PHYSICO-CHEMICAL PROPERTIES, SUBSTITUENT EFFECT, INTERACTIONS