Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (10): 1155-1158. Previous Articles     Next Articles

2-巯基噻唑[5,4-d]并嘧啶类化合物及其衍生物的合成

袁德凯;李正名;赵卫光   

  1. 南开大学元素有机化学研究所
  • 发布日期:2003-10-25

Synthesi of Thiazolo[5,4-d]pyrimindine-2-thiol and Its Derivatives

Yuan Dekai;Li Zhengming;Zhao Weiguang   

  1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University
  • Published:2003-10-25

Thiazolo [5,4-d] pyrimindine-2-thiol (4) was obtained from 6-chloro- 5-nitropyrimidine (3), sodium polysulfide carbondisulfide in one-step synthesis. A new series of 2-substituted derivatives (5) were sythesized from 4. The structures of all compounds were confirmed by ~1H NMR and elemental analysis. Biological activities of several compounds were tested.

Key words: PYRIMIDINE P;THIAZOLE P;MERCAPTO COMPOUNDS;BIOLOGICAL ACTIVITY, 1HNMR;ELEMENTAL ANALYSIS

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