Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (2): 140-149. Previous Articles     Next Articles

(3R,5R)-3,5-二羟基-6-取代己酸不对称合成研究进展

陈万锁*, 陈志荣   

  1. 浙江大学联合化学反应工程研究所 杭州 310027
  • 收稿日期:2003-03-19 修回日期:2003-06-11 接受日期:2003-06-27 发布日期:2022-09-20

New Developments in the Asymmetric Synthesis of (3R,5R)-3,5- Dihydroxyl-6-substituted Hexanoic Acid

CHEN, Wan-Suo*, CHEN, Zhi-Rong   

  1. Department of Chemical Engineering, Zhejiang University, Hangzhou 310027
  • Received:2003-03-19 Revised:2003-06-11 Accepted:2003-06-27 Published:2022-09-20
  • Contact: * E-mail: wansuochen@yahoo.com.cn; Fax: 0571-87951227.

The recent progress in the asymmetric synthesisof (3R,5R)-3,5-dihydroxyl-6-substituted hexanoic acid is reviewed, using chiral pool reaction, chiral auxiliary reaction, chiral reagent and catalyst. Thereview emphasizes the catalytic chiral reduction using 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP)-Ru(II) and catalytic chiral hydroboration reaction with chiral boranes.

Key words: (3R,5R)-3,5-dihydroxyl-6-substituted hexanoic acid, asymmetricsynthesis, development