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Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (10): 1265-1267. Previous Articles Next Articles
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张英群*,王春,李贵深,李敬慈,刘卉敏,吴秋华
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ZHANG Ying-Qun*,WANG Chun,LI Gui-Shen LI Jing-Ci,LIU Hui-Min,WU Qiu-Hua
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A novel synthesis of 3,4-dihydropyrimidin-2(1H)-ones via three-component condensation of aldehydes, β-ketoester and urea with molar ratio of 1∶1∶1.5, using expansive graphite as catalyst, was described. The reaction time was 1.5~2 h, and the yield was ranged from 72% to 93%. The inexpensive catalyst could be recovered and reused without any treatment. The products were identified by 1H NMR and IR spectra.
Key words: Biginelli reaction, expandable graphite, 3,4-dihydropyrimidin-2(1H)-one
ZHANG Ying-Qun*,WANG Chun,LI Gui-Shen LI Jing-Ci,LIU Hui-Min,WU Qiu-Hua. One-pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Expandable Graphite[J]. Chin. J. Org. Chem., 2005, 25(10): 1265-1267.
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