Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives

doi:10.6023/cjoc201507001

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (2): 283-296.DOI: 10.6023/cjoc201507001 Previous Articles Next Articles

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对映纯3,4-二氢嘧啶酮衍生物的合成研究进展

饶红红^a, 权正军^b, 白林^a, 叶鹤琳^a

a 兰州城市学院化学与环境科学院学院兰州 730070;
b 西北师范大学化学化工学院兰州 730070

收稿日期:2015-07-01 修回日期:2015-09-14 发布日期:2015-10-13
通讯作者: 饶红红 E-mail:rhh@nwnu.edu.cn
基金资助:
国家自然科学基金(Nos. 21265009, 21362032)资助项目.

Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives

Rao Honghong^a, Quan Zhengjun^b, Bai Lin^a, Ye Helin^a

a School of Chemistry and Environmental Science, Lanzhou City University, Lanzhou 730070;
b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received:2015-07-01 Revised:2015-09-14 Published:2015-10-13
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21265009, 21362032).

3,4-Dihydropyrimidinethiones are chiral molecules, however, only racemic products are isolated in the most reported Biginelli reactions. It has been proved that the absolute configuration of the C(4) stereogenic center has significant influence on the biological activity. The development in the accessing of optically active 3,4-dihydropyrimidinethiones focusing on the recent advances in the asymmetric catalytic Biginelli reactions is summarized.

Key words: enantiomerically pure 3,4-dihydropyrimidin-2-(1H)-ones, asymmetric catalysis, Biginelli reaction, multicomponent reactions

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Rao Honghong, Quan Zhengjun, Bai Lin, Ye Helin. Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives[J]. Chin. J. Org. Chem., 2016, 36(2): 283-296.

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对映纯3,4-二氢嘧啶酮衍生物的合成研究进展

Progress on the Synthesis of Enantiomerically Pure 3,4-Dihydropyrimidin-2-one Derivatives

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