Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (11): 1386-1391. Previous Articles     Next Articles

Original Articles

穿心莲内酯NO供体衍生物的合成

徐浩,黄文龙*,张惠斌,周金培   

  1. (中国药科大学新药研究中心 南京 210009)
  • 收稿日期:2005-04-08 修回日期:2005-05-18 发布日期:2005-10-30
  • 通讯作者: 黄文龙

Synthesis of the Derivatives of Andrographolide for NO Donor

XU Hao,HUANG Wen-Long*,ZHANG Hui-Bing,ZHOU Jin-Pei   

  1. (Center of Drug Research, China Pharmaceutical University, Nanjing 210009)
  • Received:2005-04-08 Revised:2005-05-18 Published:2005-10-30
  • Contact: HUANG Wen-Long

The mutual prodrug principle was applied to andrographolide derivatives. Nine compounds of NO donors were synthesized in order to find out new medicines of high bioavailability and good anticancer effect. All the target compounds have been identified by 1H NMR,13C NMR and MS spectra.

Key words: andrographolide, mutual prodrug principle, NO donor, bioavailability