Synthesis of Isoxazolines by 1,3-Dipolar Cycloaddition andTheir Bioactivity

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (11): 1392-1397. Previous Articles Next Articles

Original Articles

1,3-偶极环加成法合成异噁唑啉新化合物及其生物活性的研究

程春生*^,1,2，李志念²，苏金燕²，李涛²，张宝砚¹

(¹东北大学理学院沈阳 110004)
(²沈阳化工研究院沈阳 110021)

收稿日期:2005-04-20 修回日期:2005-05-23 发布日期:2005-10-30
通讯作者: 程春生

Synthesis of Isoxazolines by 1,3-Dipolar Cycloaddition andTheir Bioactivity

CHENG Chun-Sheng*^,1,2,LI Zhi-Nian²,SU Jin-Yan²,LI Tao²,ZHANG Bao-Yan¹

(¹ School of Sciences, Northeastern University, Shenyang 110004)
(² Shenyang Research Institute of Chemical Industry, Shenyang 110021)

Received:2005-04-20 Revised:2005-05-23 Published:2005-10-30
Contact: CHENG Chun-Sheng

Abstract

A series of new isoxazolines were prepared by 1,3-dipolar cycloaddition between different mono-substituted styrenes and new 1,3-dipolar compounds which were synthesized by the reaction of N-methylhydroxylamine sulfate with aromatic carbonyl compounds. This synthetic pathway of 5-substituted isoxazolines was an good process in green chemistry. The chemical structures of these products were characterized by ¹H NMR,¹³C NMR, COSY, HSQC and DEPT. Their bioactivity has been tested also in the laboratory, finding that some new compounds inhibited Botrytis Cinerea effectively.

Key words: NMR, MS, bioactivity, isoxazoline, 1,3-dipolar cycloaddition

Cite this article

CHENG Chun-Sheng*^,1,2,LI Zhi-Nian²,SU Jin-Yan²,LI Tao²,ZHANG Bao-Yan. Synthesis of Isoxazolines by 1,3-Dipolar Cycloaddition andTheir Bioactivity[J]. Chin. J. Org. Chem., 2005, 25(11): 1392-1397.

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1,3-偶极环加成法合成异噁唑啉新化合物及其生物活性的研究

Synthesis of Isoxazolines by 1,3-Dipolar Cycloaddition andTheir Bioactivity

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