New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (03): 292-298. Previous Articles Next Articles

Review

β-内酰胺类抗生素酶促合成新进展

吴伟波¹，王旭²，王娜¹，吴起¹，林贤福*^,1

(¹浙江大学化学系杭州 310027)
(²浙江工业大学化工与材料学院杭州 310032)

收稿日期:2005-01-27 修回日期:2005-08-11 发布日期:2006-02-28
通讯作者: 林贤福

New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics

WU Wei-Bo¹,WANG Xu²,WANG Na¹,WU Qi¹,LIN Xian-Fu*^,1

(¹Department of Chemistry, Zhejiang University, Hangzhou 310027)
(²Institute of Chemical Engineering and Material Science, Zhejiang University of Technol-ogy, Hangzhou 310032)

Received:2005-01-27 Revised:2005-08-11 Published:2006-02-28
Contact: LIN Xian-Fu

Abstract

Semi-synthetic β-lactam antibiotics plays a significant role in pharmaceutical industry. Enzymatic synthesis of β-lactam antibiotics provides an effective green technology, which could decline the generation of waste and the cost of production remarkably. This review focuses on the recent progresses of enzymatic semi-synthesis of β-lactam antibiotics, mainly including one-pot synthesis, in situ product removal, media techniques and immobilization techniques of enzyme.

Key words: penicillin, green technology, cephalosporin, enzymatic synthesis, β-lactam antibiotics

Cite this article

WU Wei-Bo,WANG Xu²,WANG Na,WU Qi,LIN Xian-Fu*^,1. New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics[J]. Chin. J. Org. Chem., 2006, 26(03): 292-298.

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β-内酰胺类抗生素酶促合成新进展

New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics

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