Cytotoxic Constituents from Bulbuphyllum inconsipicum

Abstract

A novel compound, 2-methoxy-3,4,7-trihydroxy-phenanthrene (1), along with 4-methoxy- 2,5-dihydroxy-phenathrene (2), eugenitin (3) and 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (4), was isolated from Bulbuphyllum inconsipicum. 1 and 2 suppressing HL-60 and SMMC-7721 cells were investigated in vitro with cytotoxic activity. Furthermore, synergistic inhibition of 1 and 2 with pu-erarin was assessed.

Key words: 2-methoxy-3,4,7-trihydroxy-phenanthrene, cytotoxic activity, puerarin, Bulbuphyllum inconsipicum

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TAN Gui-Shan*^,1,2,SUN Li³,CAO Jian-Guo³,WANG Xiu-Mei²,LI Fu-Shuang²
XU Kang-Ping²,DENG Yin-Hua²,YAN Dong-Lan²,ZHANG Wei²
ZHOU Ying-J. Cytotoxic Constituents from Bulbuphyllum inconsipicum[J]. Chin. J. Org. Chem., 2006, 26(03): 372-374.

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