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Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (04): 462-464. Previous Articles Next Articles
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杨华,王孝伟,陈艳丽,张志丽,刘俊义*
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YANG Hua,WANG Xiao-Wei,CHEN Yan-Li,ZHANG Zhi-Li,LIU Jun-Yi*
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A new approach to synthesis of β-ketoester derivatives was reported. As a key starting material in the synthesis of neuroprotective agents and HIV-1 RT inhibitors, Ethyl 3-oxo-(±)-6,7-di-O-isopropylidene-6,7-dihydroxyheptanoate (1) was conveniently synthe-sized from (±)-solketal and ethyl acetoacetate sodium salt through four steps of reactions. An attempt to prepare the target compound 1 by the reaction of tosylate solketal 2 and dianion of ethyl acetoacetate was unsuccessful. The structure of all compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and MS spectra.
Key words: -ketoester, synthesis, ethyl 3-oxo-(±)-6,7-di-O-isopropylidene-6,7-dihydroxyheptanoate, ethyl acetoacetate sodium salt,
YANG Hua,WANG Xiao-Wei,CHEN Yan-Li,ZHANG Zhi-Li,LIU Jun-Yi*. Study on Synthesis Ethyl 3-Oxo-(±)-6,7-di-O-isopropylidene-6,7-di-hydroxyheptanoate[J]. Chin. J. Org. Chem., 2006, 26(04): 462-464.
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