Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1448-1460.DOI: 10.6023/cjoc202001019 Previous Articles     Next Articles


陈张鹏飞, 兰文捷, 余轩, 傅滨   

  1. 中国农业大学理学院 北京 100193
  • 收稿日期:2020-01-13 修回日期:2020-03-14 发布日期:2020-03-31
  • 通讯作者: 傅滨
  • 基金资助:

New Application of β,γ-Unsaturated α-Ketoesters in Asymmetric Catalysis

ChenZhang Pengfei, Lan Wenjie, Yu Xuan, Fu Bin   

  1. College of Science, China Agricultural University, Beijing 100193
  • Received:2020-01-13 Revised:2020-03-14 Published:2020-03-31
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21572265) and the Ministry of Science and Technology of China (No. 2015BAK45B01).

β,γ-Unsaturated α-ketoester is a class of polyfunctional synthon. Due to its 1,2-dicarbonyl structure and multiple reactive sites, it has been used for the synthesis of various compounds. In the past twenty years, a number of chiral Lewis acid catalysts and organocatalysts have been applied to asymmetric catalytic reactions using β,γ-unsaturated α-ketoesters and various optically active compounds have been synthesized. The current progress of β,γ-unsaturated α-ketoesters in asymmetric catalysis according to the three different reaction sites, unsaturated acyl conjugate system, carbon-carbon double bond and carbonyl group, is summarized. Finally, the limitation of related reactions and the future development trends are also pointed out.

Key words: β,γ-unsaturated α-ketoester, asymmetric catalysis, application