Synthesis of N-Aryl-N'-(2-benzofuroyl)-thioureas and 1-Aroyl-4-(2'-benzofuroyl)-thiosemicarbazides in Aqueous Media

Abstract

A series of of N-aryl-N'-(2-benzofuroyl)-thioureas and 1-aroyl-4-(2'-benzofuroyl)- thiosemicarbazides were synthesized by the reaction of 2-benzofuroyl chloride with ammonium thiocyanate and arylamine or aroylhydrazine in the presence of benzyltriethylammonium chloride (TEBA) as catalyst via a one-step reaction in aqueous media. This strategy has the advantages of simple operation, mild reaction condition and environmental friendliness.

Key words: 1-aroyl-4-(2'-benzofuroyl)-thiosemicarbazide, water, green synthesis, N-aryl-N'-(2-benzofuroyl)-thiourea

Cite this article

WANG Xi-Cun*,ZHANG Zhang,QUAN Zheng-Jun,WANG Man-Gang
WANG Fang,LI Zheng,YANG Chun-Yan. Synthesis of N-Aryl-N'-(2-benzofuroyl)-thioureas and 1-Aroyl-4-(2'-benzofuroyl)-thiosemicarbazides in Aqueous Media[J]. Chin. J. Org. Chem., 2006, 26(07): 967-970.

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水介质中N-芳基-N'-(2-苯并呋喃甲酰基)硫脲及1-芳甲酰基-4-(2'-苯并呋喃甲酰基)氨基硫脲的合成