Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (4): 1179-1187.DOI: 10.6023/cjoc202109031 Previous Articles     Next Articles

Original article


肖剑, 武志英, 陈姿依, 赵朋飞, 刘春艳*()   

  1. 华北理工大学药学院 河北唐山 063210
  • 收稿日期:2021-09-21 修回日期:2021-11-06 发布日期:2021-12-08
  • 通讯作者: 刘春艳
  • 基金资助:

Tetraethylenepentamine Functionalized Phenolic Resin as Highly Active Acid-Base Bifunctional Catalyst for Knoevenagel Condensation Reaction

JIan Xiao, Zhiying Wu, Ziyi Chen, Pengfei Zhao   

  1. College of Pharmacy, North China University of Science and Technology, Tangshan, Hebei 063210
  • Received:2021-09-21 Revised:2021-11-06 Published:2021-12-08
  • Supported by:
    Natural Science Foundation of Hebei Province(H2020209288)

The tetraethylenepentamine functionalized phenolic resin (TEPA-PR) for Knoevenagel condensation reaction has been prepared by aminating a commercially available phenolic resin (PR) and tetraethylenepentamine. The TEPA-PR was characterized by Fourier-transfer infrared spectroscopy (FTIR), X-ray diffraction spectra (XRD) and elemental analysis (EA). The TEPA-PR can efficiently catalyze Knoevenagel condensation reaction of aromatic aldehydes with high yields of a wide range of products. Furthermore, the reaction can be easily carried out in different solvents of different polarity. The novel developed resin catalyst shows good reusability (5 times) without significant decrease of catalytic activity.

Key words: phenolic resin, acid-base catalysis, heterogeneous catalysis, Knoevenagel condensation reaction, water phase catalysis