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Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (08): 1103-1105. Previous Articles Next Articles
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肖元晶,杨守宁,石炜,杨琍苹*
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XIAOYuan-Jing,YANG Shou-Ning,SHI Wei,YANG Li-Ping*
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Asymmetric transfer hydrogenation of α-iminoketone methyl 5-[(1,1-dimethylethyl)-imino]acetyl-2-hydroxybenzoate (2) using chiral (S,S)-Ru-TsDPEN as catalyst, gave the optical pure β-amino-1-arylethanol deriva-tive methyl 5-[2-[1,1-dimethylethyl]amino]-1-hydroxyethyl]-2-hydroxyben- zoate (3), which was reduced to afford (R)-(-)-salbutamol.
Key words: α-iminoketone, (R)-salbutamol, asymmetric transfer hydrogenation, chiral (S,S)-Ru-TsDPEN catalyst
XIAOYuan-Jing,YANG Shou-Ning,SHI Wei,YANG Li-Ping*. Synthesis of (R)-Salbutamol via Asymmetric Trans-ferHydrogenation of α-Iminoketone[J]. Chin. J. Org. Chem., 2006, 26(08): 1103-1105.
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