Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (6): 1934-1951.DOI: 10.6023/cjoc202303001 Previous Articles     Next Articles


褚杨杨a,b, 韩召斌b,*(), 丁奎岭b,c,d   

  1. a 上海理工大学材料与化学学院 上海 200093
    b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
    c 上海交通大学化学化工学院 上海 200240
    d 上海交通大学变革性分子前沿科学中心 上海 200240
  • 收稿日期:2023-03-01 修回日期:2023-04-08 发布日期:2023-04-26
  • 基金资助:
    国家重点研发计划(2021YFA1500200); 国家自然科学基金(21872167); 上海市优秀学术/技术带头人计划(22XD1424800)

Progresses in the Application of Kinetic Resolution in Transition Metal Catalyzed Asymmetric (Transfer) Hydrogenation

Yangyang Chua,b, Zhaobin Hanb,*(), Kuiling Dingb,c,d   

  1. a School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
    c School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240
    d Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240
  • Received:2023-03-01 Revised:2023-04-08 Published:2023-04-26
  • Contact: E-mail:
  • Supported by:
    National Key R&D Program of China(2021YFA1500200); National Natural Science Foundation of China(21872167); Program of Shanghai Academic/Technology Research Leader(22XD1424800)

Kinetic resolution (KR) has long been a popular and classical strategy in organic synthesis to obtain optically active compounds from racemic substrates, and transition metal catalyzed asymmetric (transfer) hydrogenation is a powerful method for the synthesis of chiral compounds with high efficiency and atom economy. Over the years, a large variety of unsaturated compounds bearing different types of chiral centers have been kinetically resolved with great efficiency via asymmetric (transfer) hydrogenation using some well-established chiral transition metal catalysts, and KR has been demonstrated to be a versatile technique in the synthesis of various chiral intermediates for biologically active compounds and natural products. The research progresses in this field are summarized. Moreover, the prospects of further developments are also discussed.

Key words: kinetic resolution, asymmetric hydrogenation, asymmetric transfer hydrogenation, transition metal