Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (01): 116-119. Previous Articles     Next Articles

Reports

N-取代乙醇胺对4-氟-1-酰基苯的选择性胺化反应

戴春亚,蔡良珍,赵韧,陶晓春*   

  1. (华东理工大学应用化学研究所 上海 200237)
  • 收稿日期:2006-04-26 修回日期:2006-05-20 发布日期:2006-12-30
  • 通讯作者: 陶晓春

Selective Amination of 4-Fluoro-1-acylbenzenes UsingN-Substituted Ethanolamine

DAI Chun-Ya,CAI Liang-Zhen,ZHAO Ren,TAO Xiao-Chun*   

  1. (Institute of Applied Chemistry, East China University of Science and Technology, Shanghai 200237)
  • Received:2006-04-26 Revised:2006-05-20 Published:2006-12-30
  • Contact: TAO Xiao-Chun

A selective and simple amination of 4-fluoro-1-acylbenzenes was achieved by using N-substituted ethanolamine neatly or in amidated solvent. The procedure in the absence of metal catalysts and additional bases was carried out throughout SNAr substitution mechanism. A series of 4-[N-alkyl-N- (2-hydroxylethyl)]amino-1-acylbenzene products were characterized by elemental analysis (HRMS), IR, MS and NMR spectra.

Key words: amination, N-substituted ethanolamine, 4-fluoro-1-acylbenzene