Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (4): 1498-1526.DOI: 10.6023/cjoc202010002 Previous Articles     Next Articles



侯秋飞a, 张锐a, 梁洁媚a, 姚维忠a, 程华a,*(), 陈宬b,*()   

  1. a 湖北文理学院食品化工学院 湖北襄阳 441053
    b 武汉理工大学 材料复合新技术国家重点实验室 武汉 430070
  • 收稿日期:2020-10-02 修回日期:2020-10-27 发布日期:2020-11-04
  • 通讯作者: 程华, 陈宬
  • 基金资助:
    国家自然科学基金(21502062); 湖北省教育厅指导基金(B2019135); 湖北文理学院教师科研能力培育基金(自然科学类); 湖北文理学院教师科研能力培育基金(2018kypy001); 湖北文理学院教师科研能力培育基金(2019kypy003); 湖北文理学院学科开放基金(XK2019038)

Progress in the Synthesis of 2-Aminobenzothiazoles

Qiufei Houa, Rui Zhanga, Jiemei Lianga, Weizhong Yaoa, Hua Chenga,*(), Cheng Chenb,*()   

  1. a School of Food Science and Chemical Engineering, Hubei University of Arts and Science, Xiangyang, Hubei 441053
    b State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070
  • Received:2020-10-02 Revised:2020-10-27 Published:2020-11-04
  • Contact: Hua Cheng, Cheng Chen
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    National Natural Science Foundation of China(21502062); Scientific Research Program Guiding Project of Hubei Provincial Department of Education(B2019135); Teachers’ Scientific Research Ability Cultivation Fund of Hubei University of Arts and Science (Natural Science); Teachers’ Scientific Research Ability Cultivation Fund of Hubei University of Arts and Science(2018kypy001); Teachers’ Scientific Research Ability Cultivation Fund of Hubei University of Arts and Science(2019kypy003); Open Foundation of Discipline of Hubei University of Arts and Science(XK2019038)

2-Aminobenzothiazoles are an important class of N-heterocyclic compounds which have been widely available in numerous bioactive compounds such as pharmaceuticals and agrochemicals. Due to the versatile biological activities, great attention has been paid to their synthesis. Therefore, multitudinous synthetic approaches have been developed for accessing these compounds, including the intramolecular cyclization of arylthioureas via C—H functionalization/C—S bond formation, the intramolecular cyclization of 2-haloarylthioureas via dehydrogenative C—S bond formation, and the intermolecular C—N cross-coupling of benzothiazole with amines, 2-chlorobenzothiazole with amines, 2-aminobenzothiazole with aryl halides,etc. In this paper, the syntheses of N-substituted 2-aminobenzothiazoles are systematically reviewed, and their synthetic methods are also classified and summarized based on the varieties of the utilized substrates. Finally, the future perspective of these compounds is described.

Key words: N-substituted, 2-aminobenzothiazole, amination, C—H functionalization, C—X activation, C—N cross-coupling, cyclization, synthesis