Synthesis and Biological Activities of Novel Asymmetric Phosphonate Derivatives Containing Substituted Pyridyl

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (03): 409-413. Previous Articles Next Articles

Original Articles

新型含吡啶基的不对称膦酸酯衍生物的合成与生物活性

刘漪，石德清*，王慧利

(华中师范大学化学学院农药与化学生物学教育部重点实验室武汉 430079)

收稿日期:2006-06-26 修回日期:2006-08-29 发布日期:2007-02-13
通讯作者: 石德清

Synthesis and Biological Activities of Novel Asymmetric Phosphonate Derivatives Containing Substituted Pyridyl

LIU Yi,SHI De-Qing*,WANG Hui-Li

(Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry,
Central China Normal University, Wuhan 430079)

Received:2006-06-26 Revised:2006-08-29 Published:2007-02-13
Contact: SHI De-Qing

Abstract

10 novel asymmetric phosphonate derivatives containing substituted pyridyl were synthesized via the Michaelis-Becker reactions of 2-chloro-5-chloromethylpyridine and cyclic phosphites or dialkyl phosphites. The stereochemistry of the Michaelis-Becker reactions of cyclic phosphites is described. The preliminary biological activity tests show that the title compounds have hardly insectical activities, while most of the compounds have good fungicidal activities.

Key words: stereochemistry, fungicidal activity, cyclic phosphonate, pyridine

Cite this article

LIU Yi,SHI De-Qing*,WANG Hui-Li. Synthesis and Biological Activities of Novel Asymmetric Phosphonate Derivatives Containing Substituted Pyridyl[J]. Chin. J. Org. Chem., 2007, 27(03): 409-413.

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新型含吡啶基的不对称膦酸酯衍生物的合成与生物活性

Synthesis and Biological Activities of Novel Asymmetric Phosphonate Derivatives Containing Substituted Pyridyl

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