A Highly Efficient Paal-Knorr Synthesis of Pyrroles Catalyzed by Formic Acid at Room Temperature under Solvent-Free Conditions

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (01): 115-119. Previous Articles Next Articles

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甲酸催化的室温无溶剂条件下利用Paal-Knorr反应合成吡咯衍生物的方法

朱新海，陈功，许遵乐，万一千*

(中山大学化学与化学工程学院广州 510275)

收稿日期:2006-12-25 修回日期:1900-01-01 发布日期:2008-01-23
通讯作者: 万一千

A Highly Efficient Paal-Knorr Synthesis of Pyrroles Catalyzed by Formic Acid at Room Temperature under Solvent-Free Conditions

ZHU Xin-Hai, CHEN Gong, XU Zun-Le, WAN Yi-Qian*

(School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275)

Received:2006-12-25 Revised:1900-01-01 Published:2008-01-23

Abstract

A series of pyrroles were synthesized from primary amine (including fatty amine and aromatic amine) and acetonyl-acetone through a Paal-Knorr reaction catalyzed by formic acid at room temperature under solvent-free conditions. The advantages of this method are the mild reaction conditions, simple procedure, rapidity, easy separation of products, good yields and environmental friendliness.

Key words: formic acid, Paal-Knorr reaction, room temperature, pyrrole, solvent-free reaction

Cite this article

ZHU Xin-Hai, CHEN Gong, XU Zun-Le, WAN Yi-Qian*. A Highly Efficient Paal-Knorr Synthesis of Pyrroles Catalyzed by Formic Acid at Room Temperature under Solvent-Free Conditions[J]. Chin. J. Org. Chem., 2008, 28(01): 115-119.

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甲酸催化的室温无溶剂条件下利用Paal-Knorr反应合成吡咯衍生物的方法

A Highly Efficient Paal-Knorr Synthesis of Pyrroles Catalyzed by Formic Acid at Room Temperature under Solvent-Free Conditions

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