Deacetylation Method of Aliphatic Glycosides Catalyzed byDibutyltin Oxide

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (01): 120-122. Previous Articles Next Articles

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二丁基氧化锡脱脂肪族糖苷乙酰保护基的研究

王少敏*^,a,b，李娟^a,b，李华雨^a，刘宏民^b，李雯^c

(^a郑州大学化学系郑州 450052)
(^b郑州大学新药研究开发中心郑州 450052)
(^c郑州大学化工学院郑州 450052)

收稿日期:2007-02-07 修回日期:1900-01-01 发布日期:2008-01-23
通讯作者: 王少敏

Deacetylation Method of Aliphatic Glycosides Catalyzed byDibutyltin Oxide

WANG Shao-Min*^,a,b, LI Juan^a, LI Hua-Yu^a, LIU Hong-Min^b, LI Wen^c

(^a Department of Chemistry, Zhengzhou University, Zhengzhou 450052)
(^bNew Drug Research & Development Center, Zhengzhou University, Zhengzhou 450052)
(^c School of Chemical Engineering, Zhengzhou University, Zhengzhou 450052)

Received:2007-02-07 Revised:1900-01-01 Published:2008-01-23
Contact: WANG Shao-Min

Abstract

Deprotection of acetylated glycoside in the presence of catalytic amounts of dibutyltin oxide in methanol was described. Acetyl groups in these glycosides could be smoothly and selectively deprotected in good yields without obvious isomerizations or degradations of the sugar part under the reaction conditions. Compared to the previous methods, this new method has the advantages of simple procedure, mild condi-tions and high yields.

Key words: deacetylation, dibutyltin oxide, regioselectivity, aliphatic glycoside

Cite this article

WANG Shao-Min*^,a,b, LI Juan^a, LI Hua-Yu^a, LIU Hong-Min^b, LI Wen^c. Deacetylation Method of Aliphatic Glycosides Catalyzed byDibutyltin Oxide[J]. Chin. J. Org. Chem., 2008, 28(01): 120-122.

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二丁基氧化锡脱脂肪族糖苷乙酰保护基的研究

Deacetylation Method of Aliphatic Glycosides Catalyzed byDibutyltin Oxide

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