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Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (06): 1035-1039. Previous Articles     Next Articles

Original Articles

5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究

张培全，曾和平*   

  1. (华南理工大学化学科学学院功能分子研究所 广州 510641)
  • 收稿日期:2007-09-11 修回日期:2007-12-07 发布日期:2008-06-26
  • 通讯作者: 曾和平

Synthesis, Antioxidation Activity of 5-[2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol and Its Induction Proliferation ofMesenchymal Stem Cells

ZHANG Pei-Quan, ZENG He-Ping*   

  1. (Institute of Functional Molecules, Faculty of Chemistry, South China University of Technology, Guangzhou 510641)
  • Received:2007-09-11 Revised:2007-12-07 Published:2008-06-26
  • Contact: ZENG He-Ping

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5-[2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol (5) was synthesized and character-ized by IR, UV, 1H NMR, MS spectra and elemental analysis. Meanwhile, the stem cell activity and antioxidation activity of the title compound were investigated by the MTT and DPPH• methods. From the result it can be seen that the title compound has strong antioxidation activity and can induce the proliferation of mesenchymal stem cell under a low concentration condition.

Key words: antioxidation activity, proliferation of mes-enchymal stem cell, 5-[2-(8-hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol