Microwave-Enhanced Ullmann-Coupling Reaction of Benzimidazole with (Un)substituted Phenyl Halide

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (07): 1278-1281. Previous Articles Next Articles

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微波促进下苯并咪唑与芳基卤化物的偶联反应

刘影英 ; 陶兰* ; 冯国仁

(杭州师范大学材料与化学化工学院杭州 310036)

收稿日期:2007-12-06 修回日期:2008-01-25 发布日期:2008-07-28
通讯作者: 陶兰

Microwave-Enhanced Ullmann-Coupling Reaction of Benzimidazole with (Un)substituted Phenyl Halide

LIU, Ying-Ying; TAO, Lan*; FENG, Guo-Ren

(College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036)

Received:2007-12-06 Revised:2008-01-25 Published:2008-07-28
Contact: TAO, Lan

Abstract

The copper-catalyzed Ullmann-coupling reaction of benzimidazole with (un)substituted phenyl halide gave benzimidazole derivatives in good to excellent yields in DMSO at 75～110 ℃ under microwave irradiation conditions by using either L-proline or N,N-dimethylglycine as a ligand. This method provides a simple and inexpensive access to the title compounds. The structures of the products were confirmed by melting points, 1H NMR, 13C NMR and EI-MS spectra.

Key words: benzimidazole, (un)substituted phenyl halide, Ullmann-coupling reaction, microwave

Cite this article

LIU, Ying-Ying; TAO, Lan*; FENG, Guo-Ren. Microwave-Enhanced Ullmann-Coupling Reaction of Benzimidazole with (Un)substituted Phenyl Halide[J]. Chin. J. Org. Chem., 2008, 28(07): 1278-1281.

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微波促进下苯并咪唑与芳基卤化物的偶联反应

Microwave-Enhanced Ullmann-Coupling Reaction of Benzimidazole with (Un)substituted Phenyl Halide

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