Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (8): 2563-2569.DOI: 10.6023/cjoc202004016 Previous Articles     Next Articles

Special Issue: 有机光催化虚拟合辑


林媚a, 吴凡a, 刘天惠a, 陈志涛a, 许秀枝a, 柯方a,b   

  1. a 福建医科大学药学院 福州 350004;
    b 福建省天然药物药理学重点实验室 福州 350004
  • 收稿日期:2020-04-11 修回日期:2020-05-09 发布日期:2020-05-28
  • 通讯作者: 林媚, 柯方;
  • 基金资助:

Visible-Light Promoted Preparation of Benzimidazoles by Eosin Y Catalyzed Reaction of Benzonitrile Derivatives in Water

Lin Meia, Wu Fana, Liu Tianhuia, Chen Zhitaoa, Xu Xiuzhia, Ke Fanga,b   

  1. a Department of Pharmacy, Fujian Medical University, Fuzhou 350004;
    b Fujian Provincial Key Laboratory of Natural Medicine Pharmacolog, Fuzhou 350004
  • Received:2020-04-11 Revised:2020-05-09 Published:2020-05-28
  • Supported by:
    Project supported by the Natural Science Foundation of Fujian Province (Nos. 2016Y9052, 2016Y9053, 2017J01820).

A novel visible-light-introduced reaction for the construction of benzimidazole derivatives via radical cyclization of o-phenylenediamines with benzonitrile derivatives in water has been developed. The reaction has been achieved in high yield under mild conditions by using Eosin Y as photocatalyst, which is cheap, easy to handle and environmentally friendly. A variety of benzimidazoles were obtained in up to 91% yields. It might provide a promising protocol for the synthesis of benzimidazole derivatives.

Key words: visible-light photoredox catalysis, eosin Y, benzimidazole, catalyst