Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (02): 188-196. Previous Articles     Next Articles

Review

松香烷内酯型大戟二萜化合物的研究进展

张大永; 施连勇 ; 吴晓明*   

  1. (中国药科大学药学院 南京 210009)
  • 收稿日期:2008-05-08 修回日期:2008-06-10 发布日期:2009-02-20
  • 通讯作者: 吴晓明

Progress in ent-Abietane Euphorbiae Diterpene Lactones

Zhang, Dayong; Shi, Lianyong; Wu, Xiaoming*   

  1. (School of Pharmacy, China Pharmaceutical University, Nanjing 210009)
  • Received:2008-05-08 Revised:2008-06-10 Published:2009-02-20
  • Contact: Wu, Xiaoming

ent-Abietane diterpene lactones are extracted from the plants of Euphorbia. Their elementary structures are four-ring diterpenes. These compounds show many kinds of biological activity, especially the anti-tumor activity. In this paper, the recent progress in this kind of compounds is reviewed in detail, including the structure-activity relationships, mechanisms and the anti-tumor activity upon multiple human tumor cell lines, the potential for the development as prospective anti-tumor drugs and the prospects of the devel-opment and the directions of the research are discussed.

Key words: euphorbiae diterpene, euphorbiae fischerianae, anti-tumor activity, ent-abietane lactone