Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (04): 648-652. Previous Articles     Next Articles

Reports

外消旋2-氨基-1-(2,2-二甲基-4H-1,3-苯并二氧芑-6-基)乙醇的拆分研究

全 旭 ; 林成刚 ; 徐 娟; 史海健*   

  1. (南京工业大学化学化工学院 南京 210009)
  • 收稿日期:2008-07-04 修回日期:1900-01-01 发布日期:2009-04-20
  • 通讯作者: 史海健

Resolution of Racemic 6-(2-Amino-1-hydroxyethyl)-2,2-dimethyl- 1,3-benzodioxine

Quan, Xu; Lin, Chenggang; Xu, Juan ; Shi, Haijian*   

  1. (College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009)
  • Received:2008-07-04 Revised:1900-01-01 Published:2009-04-20
  • Contact: Shi, Haijian

An efficient preparation of (R)-6-(2-amino-1-hydroxyethyl)-2,2-dimethyl-1,3-benzodioxine by a chemical resolution in the presence of (-)-di(p-toluoyl)-L-tartaric acid was described. The yield of resolution is high, with the enantiomeric excess being more than 98%.

Key words: L-tartaric acid derivative, chemical resolution, aminoethanol