Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (06): 942-947. Previous Articles     Next Articles

Original Articles

呫吨类抗胆碱能化合物的合成研究

弓亚玲; 陆模文; 孔 博; 胡文祥*   

  1. (首都师范大学化学系 北京 100048)
  • 收稿日期:2008-09-26 修回日期:2008-12-25 发布日期:2009-06-20
  • 通讯作者: 胡文祥

Synthesis of Anticholinergic 9-Hydroxy-9-xanthenecarboxylates

Gong, Yaling; Lu, Mowen ; Kong, Bo ; Hu, Wenxiang*   

  1. (Department of Chemistry, Capital Normal University, Beijing 100048)
  • Received:2008-09-26 Revised:2008-12-25 Published:2009-06-20
  • Contact: Hu, Wenxiang

A series of new 9-hydroxy-9-xanthenecarboxylates were designed and synthesized. In the synthesis of the tricyclic group, the preparation of disubstituted xanthene derivatives was studied. In the synthesis of the amino alcohol, the 10% Pd/C was used as the catalysts, the pressure was dropped to 30 kg/cm2, the conditions for hydrogenation reactions were optimized, and the yield of the reaction was increased. For the synthesis of target compounds, the post-treatment and purification methods were improved and at the same time, the procedures were simplified.

Key words: hydroxycarboxylate, methyl 9-hydroxyl-9-xanthenecarboxylate, amino alcoh, xanthene