Synthesis and Cytotoxic Activities of 13-cis-Retinoyl  Ferrocene Derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1096-1099. Previous Articles Next Articles

Original Articles

异维A酸二茂铁基衍生物的合成及其细胞毒活性的研究

梁盛宗^a; 忻鼎丞^a ; 龙伯华^a; 向建南^*,a,b,c

(a湖南大学化学化工学院长沙 410082)
(b湖南大学生物医学工程中心长沙 410082)
(c湖南大学化学生物传感与计量学国家重点实验室长沙 410082)

收稿日期:2008-11-17 修回日期:2008-12-17 发布日期:2009-07-22
通讯作者: 向建南

Synthesis and Cytotoxic Activities of 13-cis-Retinoyl Ferrocene Derivatives

Liang, Shengzong^a; Xin, Dingchen^a; Long, Bohua^a ; Xiang, Jiannan^*,a,b,c

(a College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)
(b Bio-medicine Engineering Center, Hunan University, Changsha 410082)
(c State Key Laboratory of Chem/Biosensing and Chemometrics, Hunan University, Changsha 410082)

Received:2008-11-17 Revised:2008-12-17 Published:2009-07-22
Contact: Xiang, Jiannan

Abstract

In order to decrease toxicities of retinoids, enhance their physiological activities against cancer cells and increase absorbency in the organisms, eight novel 13-cis-retinoyl ferrocene derivatives were synthesized in yields higher than 80% through Mitsunobu reactions. Their structures were characterized and their cytotoxic activities were determined in vitro by an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using human cancer lines including A549 cells lines etc. Results showed that the 13-cis-retinoyl ferrocene derivatives modified by ferrocene groups exhibited excellent cytotoxic activities against cancer cells.

Key words: cytotoxic activity, ferrocene derivative, Mitsunobu reaction, 13-cis-retinoic acid

Cite this article

Liang, Shengzong^a; Xin, Dingchen^a; Long, Bohua^a ; Xiang, Jiannan^*,a,b,c. Synthesis and Cytotoxic Activities of 13-cis-Retinoyl Ferrocene Derivatives[J]. Chin. J. Org. Chem., 2009, 29(07): 1096-1099.

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异维A酸二茂铁基衍生物的合成及其细胞毒活性的研究

Synthesis and Cytotoxic Activities of 13-cis-Retinoyl Ferrocene Derivatives

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