Synthesis, Structure and Superoxide Dismutase-Like Activity of A New (Gly-cyl-β-alanine)(dipyrido[3,2-d:2,3-f]quinoxaline) Copper(II) Complex

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (07): 1081-1086. Previous Articles Next Articles

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(甘氨酰-β-丙氨酸)(二吡啶[3,2-d:2,3-f]喹喔啉)铜(II)配合物合成、结构及其超氧化物歧化酶活性

丁杨¹，邓剑生¹，乐学义*^,1,2

(¹华南农业大学应用化学系广州 510642)
(²华南农业大学生物材料研究所广州 510642)

收稿日期:2011-01-13 修回日期:2011-03-02 发布日期:2011-03-08
通讯作者: 乐学义 E-mail:lexy@scau.edu.cn

Synthesis, Structure and Superoxide Dismutase-Like Activity of A New (Gly-cyl-β-alanine)(dipyrido[3,2-d:2,3-f]quinoxaline) Copper(II) Complex

Ding Yang¹ Deng Jiansheng¹ Le Xueyi*^,1,2

(¹ Department of Applied Chemistry, South China Agricultural University, Guangzhou 510642)
(²Institue of Biomaterial, South China Agricultural University, Guang-zhou 510642)

Received:2011-01-13 Revised:2011-03-02 Published:2011-03-08
Contact: le xueyi E-mail:lexy@scau.edu.cn

A new complex, [Cu(Gly-β-Ala)(dpq)]•2H₂O [Gly-β-Ala＝Glycyl-β-alanine, dpq＝dipyrido [3,2-d:2,3-f]quinoxaline], has been synthesized and characterized by X-ray single crystal diffraction, elemental analysis, molar conductivity, IR and UV-Vis spectra. The complex crystallizes in triclinic space group Pī, with a＝0.70787(3) nm, b＝0.96727(4) nm, c＝0.52436(6) nm, α＝97.016(2)º, β＝100.859(2)º, γ＝108.046(2)º, V＝0.95624(7) nm³. The SOD-like activity of the complex in water solution has been measured by improved nitroblue tetrazolium (NBT)-illumination method, and the electrochemical property of the complex has been studied by cyclic voltammetry method. The results indicated that the complex possesses an excellent SOD-like activity, and the rate constant (K_Q) of the complex for catalyzing the dismutation of is 1.53×10⁷ mol^－1•L•s^－1.

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DING Yang, DENG Jian-Sheng, LE Xue-Yi. Synthesis, Structure and Superoxide Dismutase-Like Activity of A New (Gly-cyl-β-alanine)(dipyrido[3,2-d:2,3-f]quinoxaline) Copper(II) Complex[J]. Chin. J. Org. Chem., 2011, 31(07): 1081-1086.

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1 Holm, R. H.; Kennepohl, P.; Solomon E. I. Chem. Rev. 1996, 96, 2239.

2 McCord, J. M., Edeas M. A. Biomedicine and Pharmacotherapy 2005, 59, 139.

3 Zhao, Ru.;Liu, X. H.;Yin, Y.X.; Yue, J. J.; Sun, Y.; Ma, Y.; Liu, X.L. Chinese J. Org. Chem. 2003, 23, 1001(in Chinese).

(赵茹, 刘晓红, 尹宇新, 岳俊杰, 孙云, 马燕, 刘小兰, 有机化学, 2003, 23, 1001.)

4 Lin, Q. –B.; Liao, S. –R.; Xiong, Y. –H.; Le X. -Y. Chem. World 2006, 47, 378(in Chinese).

(林庆斌, 廖升荣, 熊亚红, 乐学义, 化学世界, 2006, 47, 378.)

5 Zhou, Y. H.; Fu, H.; Zhao, W. X.; Chen, W. L.; Su, C. Y.; Sun, H. Z.; Ji, L. N.; Mao, Z. W. Inorg. Chem. 2007, 46, 734.

6 Qin, S. –D.; Feng, S. i-S .; Zhang, H. –M.; Zhu, M. –L.; Yang, P. Acta Chimica Sinica 2005, 63, 1155(in Chinese).

(覃事栋, 冯思思, 张红梅, 朱苗力, 杨频, 化学学报, 2005, 63, 1155.)

7 Devereux, M.; Shea, D. O.; Connor, M. O.; Grehan, H.; Connor, Gavin.; McCann, M.; Rosair, G.; Lyng, F.; Kellett, A.; Walsh, M.; Egan, D.; Thati, B. Polyhedron 2007, 26, 4073.

8 Ferrer, E.G.; López Tévez, L. L.; Baeza, N.; Correa, M. J.; Okulik, N.; Lezama, L.; Rojo, T.; Castellano, E. E.; Piro, O. E.; Williams, P. A. M. J. Inorg. Biochem. 2007, 101, 741.

9 Hu, P.; Wu G. –W.; Xia, Q.; Mao, Z. –W. Prog. Chem. 2009, 21, 873(in Chinese).

(胡平, 吴耿伟, 夏青, 毛宗万, 化学进展, 2009, 21, 873.

10 Klanicová, A.; Trávni?ek, Z.; Van?o, J.; Popa, I.; ?indelá?, Z. Polyhedron 2010, 29, 2582.

11 Colak, A.; Terzi, ü.; Col, M.; Karaoglu, S. A.; Karab?cek, S.; Kü?ükdumlu, A.; Ayaz, F. A. Eur. J. Med.Chem. 2010, 45, 5169.

12 Abuhijleh, A. L. J. Mol. Struc. 2010, 980, 201.

13 Le, X. Y.; Liao, S. R.; Liu, X. P.; Feng, X. L. J. Coord. Chem. 2006, 59, 985.

14 Gu, Q.; Le, X. Y.; Lin, Q. B.; Liao, S. R.; Ma, X. D.; Feng, X. L. Chin. J. Chem. 2007, 25, 791.

15 Liao, S. –R.; Le X. –Y; Lin, Q. –B.; Lu, Q. –M.; Liu, X. –P.; Xiong, Y. –H.; Feng, X. -L. Chinese J. Inorg. Chem. 2006, 22, 201(in Chinese).

(廖升荣, 乐学义, 林庆斌, 卢其明, 刘小平, 熊亚红, 冯小龙, 无机化学学报, 2006, 22, 201.)

16 Liao, S. R.; Le, X. Y.; Feng, X. L. J. Coord. Chem. 2008, 61, 847.

17 Lu, Y. M.; Le, X. Y. Chinese J. Inorg. Chem. 2011, 27, 199(in Chinese).

( 卢艳梅, 乐学义, 无机化学学报, 2011, 27, 199)

18 Ding, Y.; Shen, S. –Y.; Ren, X. –X.; Liu, Y. –J.; Le, X. –Y. Chem. Bull., 2009, 72, 992(in Chinese).

(丁杨, 沈淑仪, 任祥祥, 刘英菊, 乐学义, 化学通报, 2009, 72, 992. )

19 Yang, X. –Q.; Zhang, G. –Y.; Yuan, M. –L. Ami no Aci ds & Biotic Resources 2004, 26, 49(in Chinese).

(杨小强, 张高勇,袁明龙. 氨基酸和生物资源, 2004, 26, 49.)

20 Zwelling, L. A.; Michaels, S.; Schwarts, H.; Dobson, P. P.; Kohn, K. W. Cancer. Res. 1981, 41, 640.

21 Sheldrick, G. M. SHELXTL-97, Program for X-ray crystal structure solution[CP]. G?ttingen, Germany：University of G?ttingen, 1997.

22 Zi, J. –Q.; Deng, X. –X.; Jin, Q.; Xie Y.; Li D. –Z. J. Bejing Normal University (Natural Science) 1998, 34, 101.

[ (自俊青, 邓希贤, 金虬, 谢英, 李大珍, 北京师范大学学报（自然科学版）, 1998, 34, 101. ]

23 Geary, W. J. Coord. Chem. Rev. 1971, 7, 81.

24 Nakamoto, K. Infrared and Raman Spectra of Inorganic and Coordination Compounds, 4th Edn, John Wiley and Sons Inc., New York, 1986, p. 257.

25 García-Raso, á.; Fiol, J. J.; Bartomeu, A.; Adrover, B.; Moreno, V.; Mata, I.; Espinosa, E.; Molins, E. J. Inorg. Biochem. 2003, 95, 77.

26 Bonomo, R. P.; Bruno, V.; Conte, E.; Guidi, R. D.; Mendola, D. L.; Maccarrone, G.; Nicoletti, F.; Rizzarelli, E.; Sortino, S.; Vecchio, G. Dalton Trans. 2003, 23, 4406.

27 Li, W.; Li, C. –H.; Yang, Q. –Q.; Kuang, Y. –F. Chinese. J. Inorg. Chem. 2006, 22, 101(in Chinese).

(李薇, 李昶红, 杨颖群, 匡云飞, 无机化学学报, 2006, 22, 101.)

28 Li, D. F.; Li, S.; Yang, D. X.; Yu, J. H. ; Huang, J.; Li, Y. Z.; Tang, W. X. Inorg. Chem. 2003, 42, 6071.

(甘氨酰-β-丙氨酸)(二吡啶[3,2-d:2,3-f]喹喔啉)铜(II)配合物合成、结构及其超氧化物歧化酶活性

Synthesis, Structure and Superoxide Dismutase-Like Activity of A New (Gly-cyl-β-alanine)(dipyrido[3,2-d:2,3-f]quinoxaline) Copper(II) Complex

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