Synthesis of 1,2,3,4-Tetrahydroisoquinoline Derivatives

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (07): 1087-1090. Previous Articles Next Articles

Notes

四氢异喹啉衍生物的合成研究

冯志强*^,1，杨晓莉¹，叶原丰¹，郝凌云¹，胡金刚²

(¹金陵科技学院材料工程学院南京 211169)
(²东南大学化学化工学院南京 211189)

收稿日期:2010-07-27 修回日期:2011-02-26 发布日期:2011-02-26
通讯作者: 谢宇 E-mail:xieyu_121@163.com
基金资助:
国家自然科学基金（20807021）、江西省自然科学基金（0620071）、江西省教育厅科技项目（赣教技字[2007]168号）和航空高校基金（EA200502138）;国家级.国家自然科学基金

Synthesis of 1,2,3,4-Tetrahydroisoquinoline Derivatives

Feng Zhiqiang*^,1 Yang Xiaoli¹ Ye Yuan-feng¹ Hao Lingyun¹ Hu Jingang²

(¹School of Material Engineering, Jinling Institute of Technology, Nanjing 211169)
(²School of Chemistry & Chemical Engineering, Southeast University, Nanjing 211189)

Received:2010-07-27 Revised:2011-02-26 Published:2011-02-26
Contact: Yu Xie E-mail:xieyu_121@163.com

A series of important 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized from 2-(3-methoxyphenyl)ethylamine and ethyl chloroformate by nucleophilic substitution, cyclization, Li-AlH₄ reduction and other reactions amounting to 9 steps. The structures of the products were characterized by IR, ¹H NMR spectra and elemental analysis. Compared to the traditional syn-thetic procedures of tetrahydro- isoquinoline, our procedures were temperate, convenient, economical, high-yielding and environment-friendly.

Key words: 2-(3-methoxyphenyl)ethylamine, 1,2,3,4-tetrahydroisoquinoline, cyclization

Cite this article

FENG Zhi-Qiang, YANG Xiao-Li, YE Yuan-Feng, HAO Ling-Yun, HU Jin-Gang. Synthesis of 1,2,3,4-Tetrahydroisoquinoline Derivatives[J]. Chin. J. Org. Chem., 2011, 31(07): 1087-1090.

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四氢异喹啉衍生物的合成研究

Synthesis of 1,2,3,4-Tetrahydroisoquinoline Derivatives

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