Synthesis, Crystal Structure and Antibacterical Properties of 3-CH2CH2COOCH3 Substi-tuted 1,5-Benzothiazepines

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (08): 1240-1244. Previous Articles Next Articles

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3-CH₂CH₂COOCH₃取代的1,5-苯并硫氮杂衍生物的合成、晶体结构及抑菌活性研究

张萍¹，宣烨¹，刘薇²，李媛*^,1

(¹河北师范大学化学与材料科学学院石家庄 050016)
(²河北师范大学生命科学学院石家庄 050016)

收稿日期:2010-11-10 修回日期:2011-03-01 发布日期:2011-03-29
通讯作者: 李媛 E-mail:yuanli@mail.hebtu.edu.cn

Synthesis, Crystal Structure and Antibacterical Properties of 3-CH₂CH₂COOCH₃ Substi-tuted 1,5-Benzothiazepines

Zhang Ping¹ Xuan Ye¹ Liu Wei² Li Yuan*^,1

(¹College of Chemistry, Hebei Normal University, Shijiazhuang 050016)
(² College of Life Science, Hebei Normal University, Shijiazhuang 050017)

Received:2010-11-10 Revised:2011-03-01 Published:2011-03-29

Starting from substituted benzenes, a series of 3-CH₂CH₂COOCH₃ substituted 1,5-benzothi- azepines were synthesized through 5-step reactions. The structures of the new products were confirmed by IR, ¹H NMR, ¹³C NMR, MS techniques and elemental analysis. The crystal structure of the compound 5f has been deterimined by X-ray diffraction analysis and the conformation of the seven-membered heterocycle is boat-like. The preliminary antibacterical experimental results showed that 5f and 5h have weak activities to Bacillus subtilis and Cryptococcus neoformansis.

Key words: 1,5-benzothiazepine, crystal structure, antibacterical propertiy

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ZHANG Ping, XUAN Ye, LIU Wei, LI Yuan. Synthesis, Crystal Structure and Antibacterical Properties of 3-CH₂CH₂COOCH₃ Substi-tuted 1,5-Benzothiazepines[J]. Chin. J. Org. Chem., 2011, 31(08): 1240-1244.

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3-CH₂CH₂COOCH₃取代的1,5-苯并硫氮杂衍生物的合成、晶体结构及抑菌活性研究

Synthesis, Crystal Structure and Antibacterical Properties of 3-CH₂CH₂COOCH₃ Substi-tuted 1,5-Benzothiazepines

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3-CH2CH2COOCH3取代的1,5-苯并硫氮杂衍生物的合成、晶体结构及抑菌活性研究