Crystallization-Induced Dynamic Kinetic Resolution of Phenylglycine Amide

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (9): 1495-1498. Previous Articles Next Articles

Notes

苯甘氨酰胺结晶诱导的动态动力学拆分

廖本仁^1,2，安国成²，竹俊如¹，杨帆*^,1，汤杰¹

(¹华东师范大学化学系上海 200062)
(²上海华谊集团技术研究院上海 200241)

收稿日期:2010-11-15 修回日期:2011-03-07 发布日期:2011-04-14
通讯作者: 杨帆 E-mail:fyang@chem.ecnu.edu.cn

Crystallization-Induced Dynamic Kinetic Resolution of Phenylglycine Amide

Liao Benren^1,2 An Guocheng² Zhu Junru¹ Yang Fan*^,1 Tang Jie¹

(¹Department of Chemistry, East China Normal University, Shanghai 200062)
(²Shanghai Huayi Group Technology Research Institute, Shanghai 200241)

Received:2010-11-15 Revised:2011-03-07 Published:2011-04-14
Contact: Fan Yang E-mail:fyang@chem.ecnu.edu.cn

With substituted salicylaldehyde as racemization catalyst, crystallization-induced dynamic kinetic resolution of phenylglycine amide was successfully carried out in the presence of resolving agent. Under optimized conditions, the single-run resolution yield was upward 82% with enantiomeric excess higher than 99%. The resolving agent can be recycled, and the mother liquid which contains the racemization catalyst can be reused. The average yield of the three times recycling was up to 99% with ee＞99%.

Key words: phenylglycine amide, dynamic kinetic resolution, 5-nitrosalicylaldehyde, mandelic acid

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LIAO Ben-Ren, AN Guo-Cheng, ZHU Jun-Ru, YANG Fan, TANG Jie. Crystallization-Induced Dynamic Kinetic Resolution of Phenylglycine Amide[J]. Chin. J. Org. Chem., 2011, 31(9): 1495-1498.

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苯甘氨酰胺结晶诱导的动态动力学拆分

Crystallization-Induced Dynamic Kinetic Resolution of Phenylglycine Amide

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