Three Component One-Pot Synthesis of 6-Amino-4-phenyl-3-iso- propyl-1-phenyl-4H-pyrano[2,3-c]pyrazol-5-carbonitrile

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (9): 1499-1503. Previous Articles Next Articles

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6-氨基-4-芳基-3-异丙基-1-苯基-4H-吡喃[2,3-c]吡唑-5-腈的三组分一锅法合成

祖力皮牙•买买提，阿布拉江•克依木*，孙万赋

(新疆大学化学化工学院乌鲁木齐 830046)

收稿日期:2010-09-21 修回日期:2011-11-27 发布日期:2011-04-28

Three Component One-Pot Synthesis of 6-Amino-4-phenyl-3-iso- propyl-1-phenyl-4H-pyrano[2,3-c]pyrazol-5-carbonitrile

ZU Li-Pi-Ya-•Mai-Mai-Ti, A Bu-La-Jiang-•Ke-Yi-Mu, SUN Wan-Fu

(College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046)

Received:2010-09-21 Revised:2011-11-27 Published:2011-04-28

A series of 6-amino-4-phenyl-3-isopropyl-1-phenyl-4H-pyrano[2,3-c]pyrazol-5-carbonitriles (4a～4j) were synthesized via three-component one-pot reaction of 3-isopropyl-1-phenylpyrazol-5-one, arylaldehydes and malononitrile under the catalysis of triethylamine. Comparing to the conventional method, the one-pot synthesis has several advantages such as simple work-up and good yield. All products were characterized by IR, ¹H NMR and MS techniques.

Key words: pyrano[2,3-c]pyrazole, three-component reaction, one-pot synthesis

Cite this article

ZU Li-Pi-Ya-?Mai-Mai-Ti, A Bu-La-Jiang-?Ke-Yi-Mu, SUN Wan-Fu. Three Component One-Pot Synthesis of 6-Amino-4-phenyl-3-iso- propyl-1-phenyl-4H-pyrano[2,3-c]pyrazol-5-carbonitrile[J]. Chin. J. Org. Chem., 2011, 31(9): 1499-1503.

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6-氨基-4-芳基-3-异丙基-1-苯基-4H-吡喃[2,3-c]吡唑-5-腈的三组分一锅法合成

Three Component One-Pot Synthesis of 6-Amino-4-phenyl-3-iso- propyl-1-phenyl-4H-pyrano[2,3-c]pyrazol-5-carbonitrile

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