Simulation of Esterase with Bifunctional Organic Molecules

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (04): 569-574. Previous Articles Next Articles

Original Articles

双功能有机小分子模拟酯酶研究

杨锦耀; 李雪明 ; 董立亭 ; 宣宜宁 ; 鄢明*; 姚英明

(a苏州大学化学化工学院苏州 215123)
(b中山大学药学院精细化工与合成药物工业研究院广州 510006)

收稿日期:2008-04-30 修回日期:2008-09-11 发布日期:2009-04-20
通讯作者: 鄢明

Simulation of Esterase with Bifunctional Organic Molecules

Yang, Jingyao ; Li, Xueming; Dong, Liting; Xuan, Yining;
Yan, Ming*; Yao, Yingming

(a Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123)
(b School of Pharmaceutical Sciences, Industrial Institute of Fine Chemicals and Synthetic Drugs,
Sun Yat-sen University, Guangzhou 510006)

Received:2008-04-30 Revised:2008-09-11 Published:2009-04-20
Contact: Yan, Ming

Abstract

Three bifunctional organic catalysts with thiourea (or urea) and imidazole groups were designed and synthesized. Their catalytic activities for hydrolysis of p-nitrophenyl acetate (PNPA) were studied by UV spectrum. The dependence of rate constants on pH was also examined. The bifunctional organic catalysts showed higher catalytic activities than the monofunctional catalyst only with thiourea group.

Key words: enzyme mimic, bifunctional organic molecule, imidazole, hydrolysis, thiourea, nitrophenyl acetate

Cite this article

Yang, Jingyao ; Li, Xueming; Dong, Liting; Xuan, Yining;
Yan, Ming*; Yao, Yingming
. Simulation of Esterase with Bifunctional Organic Molecules[J]. Chin. J. Org. Chem., 2009, 29(04): 569-574.

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双功能有机小分子模拟酯酶研究

Simulation of Esterase with Bifunctional Organic Molecules

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