Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (1): 18-40.DOI: 10.6023/cjoc202306003 Previous Articles     Next Articles



贾小英a,b, 普佳霞a,b, 韩丽荣a,b, 李清寒a,b,*()   

  1. a 西南民族大学化学与环境学院 成都 610041
    b 西南民族大学 国家民委化学基础重点实验室 成都 610041
  • 收稿日期:2023-06-02 修回日期:2023-07-28 发布日期:2023-08-30
  • 基金资助:
    西南民族大学中央高校学生项目(2022NYXXS081); 及国家民委基础化学重点实验室平台建设(ZYN2023106)

Research Progress in the Synthesis of Benzo[d]pentamembered Heterocyclic Thioethers Containing Two Heteroatoms

Xiaoying Jiaa,b, Jiaxia Pua,b, Lirong Hana,b, Qinghan Lia,b()   

  1. a College of Chemistry and Environment, Southwest Minzu University, Chengdu 610041
    b Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, Southwest Minzu University, Chengdu 610041
  • Received:2023-06-02 Revised:2023-07-28 Published:2023-08-30
  • Contact: *E-mail:
  • Supported by:
    Central University Foundation Student Program of Southwest Minzu University(2022NYXXS081); the Key Laboratory of General Chemistry of the National Ethnic Affairs Commission Support Program(ZYN2023106)

The thioether structure of benzo[d]penta-membered heterocycles with double heteroatoms, such as benzo[d] thiazole/oxazole/imidazole, widely exists in many drug molecules and natural product molecules. Its derivatives have extensive biological activities such as antibacterial, antiviral and anti-tumor, and are also important intermediates in organic synthesis and structural units in drug synthesis. Therefore, benzo[d]thiazole/oxazole/imidazole sulfide compounds have great application value in medicine, materials and other fields. The research of its synthesis method has also become one of the current research hotspots. The synthesis methods and biological activity research progress of benzo[d]five membered heterocyclic sulfide compounds with double heteroatoms in recent years are reviewed, and some of their reaction mechanisms are described.

Key words: benzo[d]thiazole sulfide, benzo[d]oxazole sulfide, benzo[d]imidazole sulfide, C—S bond formation, research progress