Synthesis and Biological Evaluation of the Diacid Solanesyl Glycosyl Esters

Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (10): 1102-1106. Previous Articles Next Articles

二元酸茄呢醇乳糖和麦芽糖酯合成及生是活性测试研究

王超杰;宋金勇;赵瑾

河南大学

发布日期:2003-10-25

Synthesis and Biological Evaluation of the Diacid Solanesyl Glycosyl Esters

Wang Chaojie;Song Jinyong;Zhao Jin

Key Laboratory of Special Functional Materials, Henan University

Published:2003-10-25

Abstract

Fourteen diacid solanesyl glycosyl esters were synthesized by the reaction of O-acetyllactopyranosyl bromide or O-acetylmaltopyranosyl bromide with diacid solanesyl monoesters, using tetrabutyl ammonium bromide as a phase-transfer catalyst. All of them are new compounds, and their structures were confirmed by IR, ~1H NMR, MS spectra and elemental analysis. Six of the target compounds were tested preliminarily in vitro for their anti-tumor activity on KB, Bel-7402 and HCT-8 cells.

Key words: LACTOSE;MALTOSE;ELEMENTAL ANALYSIS;IR;1HNMR;MS;BIOLOGICAL ACTIVITY, diacid solanesyl glycosyl ester;ANTITUMOR DRUGS

CLC Number:

R914

Cite this article

Wang Chaojie;Song Jinyong;Zhao Jin. Synthesis and Biological Evaluation of the Diacid Solanesyl Glycosyl Esters[J]. Chin. J. Org. Chem., 2003, 23(10): 1102-1106.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	SUN Jian, SHENG Yuan, XIE Qiong, CHOU Zhui-Bai. One-Pot Synthesis of 6-Methoxy-1,2,3,9-tetrahydro-4H- carbazol-4-one Oxime [J]. Chin. J. Org. Chem., 2011, 31(03): 362-364.
[2]	XU Gang, WEN Fu-Hua, MAI Xiao-pang, SUN Ping-Hua, HUANG Mei-Yan, CHEN Wei-Min. Asymmetric Synthesis and Biological Evaluation of Cholinesterase Inhibitor Rivastigmine and Analogues Thereof [J]. Chin. J. Org. Chem., 2010, 30(08): 1185-1191.
[3]	Zhao Jin;Song Jinyong;Wang Chaojie. Synthesis of 4-N-Solanesylamino-benzoic Acid Glycosyl Esters [J]. Chin. J. Org. Chem., 2003, 23(7): 714-716.
[4]	Tao Chunyuan;Lu Qun;Shuai Min. Synthesis of Chiral 1-β-Carboxyethylgermatranes [J]. Chin. J. Org. Chem., 2003, 23(7): 717-719.
[5]	Xu Di;Pang Chaole;Guo Xindong;Ma Lin;Gu Lianquan. Tyrosinase Catalyzed Reaction of 4-Substituted-phenol wth Aryl Amine [J]. Chin. J. Org. Chem., 2003, 23(7): 724-727.
[6]	Liu Jianli. Biomimetic Synthesis of Camptothecin: A Story of Quarter Century [J]. Chin. J. Org. Chem., 2003, 23(5): 432-437.
[7]	Yin Handong;Wang Chuanhua;Ma Chunlin. Synthesis, Anti-tumour Properties and Crystal Structure of Bis { oxo-bis[ (2-furylcarboxylato)dibenzyltin(IV) ]} [J]. Chin. J. Org. Chem., 2003, 23(5): 475-478.
[8]	Tian Laijin;Yu Qingsen;Liu Xijie;Shang Zhicai;Wang Tao;Zhao Wenna. Synthesis and Structural Characterization of 3- Trichlorostannylpropionates and Their Complexes [J]. Chin. J. Org. Chem., 2003, 23(5): 441-446.
[9]	Peng Bin;Sun LiJuan;Chang WeiXing;Xie QinLan. Syntheses and Study of Diorganotin Ferrocenoates [J]. Chin. J. Org. Chem., 2003, 23(4): 344-349.
[10]	Ren YuJie;Jia CuiYing;Zhao YuMei;Li Ping;Li Hua;Chen HuiLin. Synthesis and Properties of (Z)-1-[2-(Tribenzyistannyl) vinyl]-l- cycioheptanol and Its Benzylhalostannyl Derivatives [J]. Chin. J. Org. Chem., 2003, 23(4): 372-374.
[11]	Li Chunxia;Li Yingxia;Yu Lingbo;Chu Shidong;Cuan Huashi. Synthesis of the Galactoglycerolipids [J]. Chin. J. Org. Chem., 2003, 23(1): 66-71.
[12]	Wang Wenjun;Dai Qianhuan;Chen Sha. Oxidation and Degradation of the Sclareol Side Chain [J]. Chin. J. Org. Chem., 2003, 23(1): 95-99.
[13]	Xie Wenlin;Ma Lin;Guo Gangjun;Duan Zhifang;Chen Mei;Gu Lianquan. Synthesis and Biological Activities of N-Substituted-6-arylthio- pyridinones [J]. Chin. J. Org. Chem., 2002, 22(12): 999-1003.
[14]	Xia Lijun;Tang Minhua;Ding Zuoding;Lin Lin;Luo Hongfeng;He Rong. Separation of Enantiomers of Flurbiprofen, Ropivacaine Hydrochloride, Cetrizine and trans-2-Phenylcyclopropylboronic Acid on a Chiral-AGP [J]. Chin. J. Org. Chem., 2002, 22(12): 1018-1021.
[15]	Shi Daqing;Wang Xiangshan;Tu Shujiang. Synthesis of 4H-Chromene Derivatives Catalyzed by KF/Al_2O_3 [J]. Chin. J. Org. Chem., 2002, 22(12): 1053-1056.

二元酸茄呢醇乳糖和麦芽糖酯合成及生是活性测试研究

Synthesis and Biological Evaluation of the Diacid Solanesyl Glycosyl Esters

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments